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43 Genentech has already demonstrated in a Phase 1b clinical trial (ClinicalTrials.gov NCT03060538) that the subcutaneous injection of BFKB8488A was safe and adequately tolerated, with nausea as the most significant adverse effect
Although individual studies have reported varying outcomes, the cumulative evidence suggests a consistent, modest and yet clinically important reduction in blood pressure associated with GLP-1RAs
MSC-focused analyses report improvements in neurological deficits and activities of daily living [46,47,48,49,50], whereas the Cochrane review emphasizes uncertainty and the need for larger, well-controlled trials [47]
Some people find this more comfortable because the injection feels more substantial, while others prefer smaller volumes to minimize injection site reactions
